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Modern scientific tests have implicated the Hippo pathway and its transcriptional effectors YAP and TAZ as necessary for fibroblast activation and tissue fibrosis. To check the particular and enough roles for TAZ in driving autonomous fibroblast activation, we cultured NIH3T3 fibroblasts expressing a doxycycline-inducible nuclear-localized mutant o
The authors declare which the research was executed while in the absence of any professional or economic associations which could be construed as a potential conflict of interest.We then assessed irrespective of whether this surprising binding product is unique to TM2 compared to other acknowledged TEAD inhibitors. On condition that reported TEAD i
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